Caspases

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  • soubiri
    أعضاء رسميون
    • May 2006
    • 1459

    Caspases

    <p class="MsoNormal" dir="rtl" style="margin: 0cm 0cm 10pt; tab-stops: 64.2pt"><b><span lang="AR-SA" style="font-family: &quot;arial&quot;,&quot;sans-serif&quot;; mso-ascii-font-family: calibri; mso-hansi-font-family: calibri; mso-bidi-font-family: arial; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-theme-font: minor-bidi">السلام عليكم<span style="mso-tab-count: 1">       </span><p></p></span></b></p><p class="MsoNormal" dir="rtl" style="margin: 0cm 0cm 10pt"><span lang="AR-SA" style="font-family: &quot;arial&quot;,&quot;sans-serif&quot;; mso-ascii-font-family: calibri; mso-hansi-font-family: calibri; mso-ansi-language: fr; mso-bidi-font-family: arial; mso-ascii-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-theme-font: minor-bidi">هل من مقابل عربي للمصطلح المبين أسفله؟<p></p></span></p><p dir="ltr" style="background: #f8fcff"><b><span lang="EN" style="font-size: 12.5pt; color: black; font-family: &quot;arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: en">Caspases</span></b><span lang="EN" style="font-size: 12.5pt; color: black; font-family: &quot;arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: en"> are <a title="Enzyme" href="http://en.wikipedia.org/wiki/Enzyme"><font color="#002bb8">enzymes</font></a> known as <a title="Protease" href="http://en.wikipedia.org/wiki/Protease"><font color="#002bb8">proteases</font></a>, which play essential roles in <a title="Apoptosis" href="http://en.wikipedia.org/wiki/Apoptosis"><font color="#002bb8">apoptosis</font></a> (cell death) and <a title="Inflammation" href="http://en.wikipedia.org/wiki/Inflammation"><font color="#002bb8">inflammation</font></a>. As proteases, they are enzymes that cleave (cut) other proteins. They are called <a title="Cysteine protease" href="http://en.wikipedia.org/wiki/Cysteine_protease"><font color="#002bb8">cysteine proteases</font></a>, because they use a <a title="Cysteine" href="http://en.wikipedia.org/wiki/Cysteine"><font color="#002bb8">cysteine</font></a> residue to cut those proteins, and called caspases because the cysteine residue cleaves their <a title="Substrate" href="http://en.wikipedia.org/wiki/Substrate"><font color="#002bb8">substrate</font></a> proteins at the <a title="Aspartic acid" href="http://en.wikipedia.org/wiki/Aspartic_acid"><font color="#002bb8">aspartic acid</font></a> residue.<p></p></span></p><p dir="ltr" style="background: #f8fcff"><span lang="EN" style="font-size: 12.5pt; color: black; font-family: &quot;arial&quot;,&quot;sans-serif&quot;; mso-ansi-language: en">Caspases are essential in <a title="Cell (biology)" href="http://en.wikipedia.org/wiki/Cell_(biology)"><font color="#002bb8">cells</font></a> for <a title="Apoptosis" href="http://en.wikipedia.org/wiki/Apoptosis"><font color="#002bb8">apoptosis</font></a>, one of the main types of programmed cell death in <a title="Developmental biology" href="http://en.wikipedia.org/wiki/Developmental_biology"><font color="#002bb8">development</font></a> and most other stages of adult life, and have been termed "executioner" proteins for their roles in the cell. Some caspases are also required in the <a title="Immune system" href="http://en.wikipedia.org/wiki/Immune_system"><font color="#002bb8">immune system</font></a> for the maturation of <a title="Cytokines" href="http://en.wikipedia.org/wiki/Cytokines"><font color="#002bb8">cytokines</font></a>. Failure of apoptosis is one of the main contributions to <a title="Tumour" href="http://en.wikipedia.org/wiki/Tumour"><font color="#002bb8">tumour</font></a> development and autoimmune diseases; this coupled with the unwanted apoptosis that occurs with <a title="Ischaemia" href="http://en.wikipedia.org/wiki/Ischaemia"><font color="#002bb8">ischaemia</font></a> or <a title="Alzheimer's disease" href="http://en.wikipedia.org/wiki/Alzheimer's_disease"><font color="#002bb8">Alzheimer's disease</font></a>, has boomed the interest in caspases as potential therapeutic targets since they were discovered in the mid 1990s.<p></p></span></p><p class="MsoNormal" dir="ltr" style="margin: 0cm 0cm 10pt; direction: ltr; unicode-bidi: embed; text-align: left"><span lang="EN" style="mso-ansi-language: en"><a href="http://en.wikipedia.org/wiki/Caspase"><font face="Calibri">http://en.wikipedia.org/wiki/Caspase</font></a><p></p></span></p><p class="MsoNormal" dir="ltr" style="margin: 0cm 0cm 10pt; direction: ltr; unicode-bidi: embed; text-align: left"><span lang="FR" style="mso-ansi-language: fr"><p><font face="Calibri"> </font></p></span></p><p></p>
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  • Aratype
    مشرف
    • Jul 2007
    • 1629

    #2
    _MD_RE: Caspases

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